Sabyasachi Dash

Company: Alexion-AstraZeneca Rare Disease

Job title: Senior Scientist

Seminars:

Roundtable Discussion: Exploring Challenges & Opportunities for Advancing Delivery of Brain-Targeted Therapeutics 2:30 pm

More practical and highly interactive breakout roundtables where attendees can crowd-source solutions and share opinions around pre-assigned topic areas: Exploring new shuttle targets and analysis of their polarized expression and trafficking machinery How can we couple advances in medicinal chemistry to develop small molecules to treat rare diseases in the CNS? Which innovations prove most…Read more

day: Conference Day One

Panel Discussion: Evaluating In Vivo & In Vitro Systems to Effectively Model Transportation of Neurological & Neuro-Oncology Drugs to the CNS 8:30 am

From microfluidics to BBB chips to organoids: which in vitro systems show greatest translational relevance? What must be improved in in vivo recapitulations of BBB to achieve reliable drug read outs that can be used in human trials? How can we achieve greater confidence in in vitro systems to replicate human BBB biology? How can…Read more

day: Conference Day One

Getting Back to Basics: Fundamental Principals of Blood-Brain Barrier Properties Under Normal & Disease Conditions 8:40 am

Before developing novel therapies in the hope to achieve BBB penetration, it is critical to address fundamental gaps in the understanding of blood-brain barrier biology, permeability, and transcytosis mechanisms. • How can we evolve knowledge of normal BBB anatomy, receptor expression and functionality before progressing to disease conditions? • How can we harness in vivo…Read more

day: Pre-Conference Track 1 AM