Getting Back to Basics: Fundamental Principals of Blood-Brain Barrier Properties Under Normal & Disease Conditions

Time: 8:40 am
day: Pre-Conference Track 1 AM


Before developing novel therapies in the hope to achieve BBB penetration, it is critical to address fundamental gaps in the understanding of blood-brain barrier biology, permeability, and transcytosis mechanisms.

• How can we evolve knowledge of normal BBB anatomy, receptor expression and functionality before progressing to disease conditions?

• How can we harness in vivo model systems to capture changes in BBB and validate gene expression observations from human samples to understand disease-induced alterations to the BBB?

• What can be learned from past failings to inform future design of carrier systems based on underlying disease processes and biology?