Adem Koksal
Company: Biogen
Job title: Director - Scientific & Biologics Drug Discovery
Seminars:
Chair’s Closing Remarks 5:15 pm
day: Conference Day One
Panel Discussion: Evaluating In Vivo & In Vitro Systems to Effectively Model Transportation of Neurological & Neuro-Oncology Drugs to the CNS 8:30 am
From microfluidics to BBB chips to organoids: which in vitro systems show greatest translational relevance? What must be improved in in vivo recapitulations of BBB to achieve reliable drug read outs that can be used in human trials? How can we achieve greater confidence in in vitro systems to replicate human BBB biology? How can…Read more
day: Conference Day One
Chair’s Opening Remarks 8:20 am
day: Conference Day One
Searching Beyond Transferrin Receptor 1 for Brain Endothelial Cell-Specific Facilitators of Antibody Delivery Across the Blood-Brain Barrier 11:05 am
Ubiquitous expression of TfR1 continues to hold back specific and efficient uptake of antibodies targeting the CNS, therefore enhancing the need for receptors selective for BECs to prevent peripheral toxicity. • What are the efforts going into identifying new receptors and steering the transcytosis activity of specific receptors to a particular tissue? • How can…Read more
day: Pre-Conference Track 1 AM