Searching Beyond Transferrin Receptor 1 for Brain Endothelial Cell-Specific Facilitators of Antibody Delivery Across the Blood-Brain Barrier

Time: 11:05 am
day: Pre-Conference Track 1 AM


Ubiquitous expression of TfR1 continues to hold back specific and efficient uptake of antibodies targeting the CNS, therefore enhancing the need for receptors selective for BECs to prevent peripheral toxicity.

• What are the efforts going into identifying new receptors and steering the transcytosis activity of specific receptors to a particular tissue?

• How can we mitigate challenges of peripheral exposure associated with transferrin receptor-mediated delivery?