Integrating Systemic & Direct Delivery Approaches – Breaking Down the Silos
1:00 pm - Tuesday 1st December 2026
Challenging the artificial separation between systemic and direct delivery, exploring how these complementary approaches can work in unison rather than competition to advance CNS therapeutics.
This workshop will gather experts to:
- Challenge the “invasiveness stigma” by comparing direct CNS delivery to widely accepted neurosurgical procedures like DBS electrode placement, examining why one is embraced while the other faces resistance
- Understand CSF circulation dynamics and anatomical constraints that determine when intrathecal delivery fails versus when intraventricular or cisternal approaches succeed, optimizing delivery route selection
- Design rational decision frameworks for selecting systemic versus direct delivery based on disease location, patient population, dosing frequency, and therapeutic window requirements
Speakers:
Former Executive Director of Engineering, DDCS (Delivery, Device, & Connected Solutions)
Eli Lilly
