Christopher Kadamus
Former Executive Director of Engineering, DDCS (Delivery, Device, & Connected Solutions) Eli Lilly
Seminars
As the number of available CNS delivery technologies continues to expand, developers face a growing challenge: determining which approach is best suited to their specific therapeutic goal. While BBB shuttles, intrathecal administration, implantable devices, focused ultrasound, gene therapy vectors and emerging non-invasive approaches each offer unique advantages, their suitability can vary dramatically depending on the target, modality, disease biology and patient population. This interactive workshop will move beyond debates around which technology is ‘best’ to explore how developers can build fit for- purpose delivery strategies that maximize clinical, operational and commercial success.
This Workshop Will Gather Experts To:
- Define how factors including target location, therapeutic modality, required biodistribution and dosing frequency should influence CNS delivery strategy selection
- Compare where systemic delivery, direct CNS administration, device-enabled approaches and BBB modulation technologies offer the greatest advantages across different disease settings
- Explore the trade-offs between efficacy, safety, patient burden, operational complexity and scalability when evaluating delivery options for chronic versus acute indications
- Develop a practical framework for matching delivery technologies to specific program goals, therapeutic modalities and target product profiles
- Understanding patient and caregiver preferences on delivery route frequency and invasiveness to inform the design of brain shuttle and systemic platforms
- Evaluating tolerability safety perceptions and adherence challenges associated with next generation brain delivery approaches across real-world care settings
- Capturing patient perspectives on monitoring burden digital endpoints and treatment impact to guide clinically meaningful endpoint selection
- Identifying barriers to access and uptake of advanced CNS delivery technologies and defining strategies to ensure equitable and scalable implementation
