Enhancing Therapeutic Distribution Beyond Areas Adjacent to the Site of Intra-CSF or Intranasal Administration

Time: 2:05 pm
day: Pre-Conference Track 2 PM


To maximize potential of intra-CSF or intranasal delivery, it is important to overcome barriers imposed by neuroanatomy and CSF flow to aid diffusion to deeper brain regions.

• How can we deepen exposure to concentrated regions, such as the mid brain and striatum, following direct dosing into the CSF or nasal cavity?

• Which cases are most beneficial to consider IT, ICV or IN dosing over systemic delivery?