Demonstrating Successful Blood-Brain Barrier Penetration of AAVs in Rodent Models to Optimize Gene Delivery for Neurological Disorders
Time: 12:00 pm
day: Conference Day One
Details:
- Leveraging in vivo screening approaches to identify Transferrin Receptor-specific antibodies to support BBB crossing of conjugated AAVs
- Utilizing specific capsid mutations to abolish natural glycan binding and minimize peripheral targeting of undesired tissues
- Comparing ICV and IV route for AAV targeting to the mouse brain
