Willard Costain

Company: Government of Canada

Job title: Senior Research Officer

Seminars:

Panel Discussion | Advancing In Vitro Models to Better Recapitulate the Blood-Brain Barrier: Future Directions & Innovations to Ensure Translatability 9:30 am

What are the critical gaps in current in vitro BBB models that hinder their predictive accuracy? How can we better integrate multiple cell types, including fibroblasts and immune components, to replicate the BBB’s immune environment? How can in vitro models better reflect intracellular trafficking and sorting processes critical to BBB transcytosis? When and how should…Read more

day: Day Two - Morning

Evaluating the Potential of Alternative Receptors Beyond TfR1 to Enhance CNS Access 12:00 pm

What properties make a receptor suitable for CNS transcytosis? How do you evaluate receptor internalization and trafficking? Are we reaching the limits of TfR, or is there more to explore? What’s needed to validate a “novel” receptor target clinically? Couple single-domain antibodies to Fc regions or other antibodies to enhance pharmacokinetics and prolong half-lifeRead more

day: Day Two - Morning - Track A