Suganya Selvarajah

Company: Attralus

Job title: Director of Biology

Seminars:

Highlighting Success in Antibody Shuttle-Mediated Transportation for Amyloid-Targeted Therapeutics 2:45 pm

Identifying the optimal bispecific antibody format for maximizing CNS exposure AT-07, the conjugation of AT-04 to a VNAR-derived brain shuttle, enhanced brain penetration in a mouse model and has the potential to increase effectiveness in clearing neuropathic fibrillar deposits AT-07 demonstrated a 10-fold increase in brain penetration versus AT-04 in a PK study in wild-type…Read more

day: Conference Day Two

Panel Discussion: Evaluating In Vivo & In Vitro Systems to Effectively Model Transportation of Neurological & Neuro-Oncology Drugs to the CNS 8:30 am

From microfluidics to BBB chips to organoids: which in vitro systems show greatest translational relevance? What must be improved in in vivo recapitulations of BBB to achieve reliable drug read outs that can be used in human trials? How can we achieve greater confidence in in vitro systems to replicate human BBB biology? How can…Read more

day: Conference Day One