Rachael Miller

Company: University of Massachusetts Medical School

Job title: Research Scientist

Seminars:

11.30 Roundtable Discussion: Exploring Strategies to Enhance CSF Compatibility 11:30 am

More practical and highly interactive breakout roundtables where attendees can crowd-source solutions and share opinions around pre-assigned topic areas: Physical chemistry considerations: How can we optimize properties such as viscosity, density, osmolarity, and diffusivity to ensure the drug resides in the target brain region? How does CSF generation transport and clearance bot facilitate and hinder…Read more

day: Day Two Track 2 AM

11.00 Optimizing the Formulation of CSF-Administered RNA Therapeutics to Prevent Neurotoxicity 11:00 am

Understanding how CSF formulation differs to plasma formulation Considerations for how concentrated the drug formulation can be to avoid localized toxicity in the lumbar spine, cisterna magna or ventricles Optimizing the pH to prevent compromising the ionic environment of the CSFRead more

day: Day Two Track 2 AM