Mathias Schmidt

Company: ArmaGen

Job title: Executive Fellow JCR Pharmaceuticals

Seminars:

Rethinking the Receptor Landscape for CNS Drug Delivery: Exploring Alternative Targets Beyond Transferrin for Receptor-Mediated Transport 9:00 am

Instead of relying solely on well-known receptor pathways, a new wave of research is uncovering alternative BBB targets with the potential to transform CNS drug delivery. By mapping receptor expression, engineering ligands for precision engagement, and harnessing receptor recycling, scientists are expanding the range of shuttle systems beyond transferrin. This workshop will examine the translational…Read more

day: Workshop A

Novel AAV Capsids Enable Modular Tropism for Brain, Liver & Muscle with Minimized Hepatotoxicity 1:30 pm

Engineering capsids with surface-displayed mini antibodies to facilitate receptor-mediated transcytosis across the blood-brain barrier Introducing targeted mutations in capsid loop regions to abrogate liver receptor binding, achieving a reduction in hepatic tropism Incorporating muscle-specific targeting peptides to create a modular vector platform with tuneable multi-organ tropism profilesRead more

day: Day One - Afternoon - Track A