Panel Discussion: Direct vs Systemic Delivery: Driving Pharma Buy-In, Bottlenecks & Patient Perception
2:30 pm - Thursday 3rd December 2026
- Compare direct CNS delivery and systemic administration in terms of tissue exposure and selectivity, and their impact on target-site concentration, dose, and efficacy–toxicity balance
- Assess the limitations of systemic approaches that rely on plasma pharmacokinetics as a surrogate for efficacy versus direct delivery strategies that prioritise disease-site exposure
- Evaluate adoption barriers and translational challenges for direct delivery relative to systemic modalities, including device integration and demonstration of tissue-level pharmacological advantage
- Explore how patient, clinician, and commercial perspectives shape trade-offs between invasiveness and the potential for improved efficacy and reduced toxicity through targeted delivery
