Lost in Translation: Replicating Proof-of-Concept Studies for Intra-CSF Delivery Methods in Clinical Practice

Time: 11:05 am
day: Pre-Conference Track 2 AM


Physiological cross species differences remain a critical barrier to scaling up doses across in vivo intra-CSF studies, therefore emphasizing the need to enhance translatability of rodent and non-human primate models to study CNS drug delivery.

• How can we navigate differences in quality and preparation standards to successfully scale up injection doses from mouse to non-human primate to human?

• How do you determine successful delivery in animal brains and how does this translate to human models displaying different disease properties?

• How can we enhance translatability of imaging studies in animals to visualize drug biodistribution?