11.00 Optimizing the Formulation of CSF-Administered RNA Therapeutics to Prevent Neurotoxicity
Time: 11:00 am
day: Day Two Track 2 AM
Details:
- Understanding how CSF formulation differs to plasma formulation
- Considerations for how concentrated the drug formulation can be to avoid localized toxicity in the lumbar spine, cisterna magna or ventricles
- Optimizing the pH to prevent compromising the ionic environment of the CSF
