Jamie Tsung
Director, Drug Product Formulation, CMC Development Alnylam Pharmaceuticals
Seminars
Wednesday 10th December 2025
Roundtable Discussion: Not All Modalities Are Created Equal: Overcoming Formulation Challenges in Intrathecal Delivery to Speed CMC & Improve Patient Outcomes
11:40 am
- How do different modalities uniquely challenge formulation for safe and effective intrathecal delivery?
- What formulation strategies – buffers, excipients, conjugates – are proving most effective or problematic for IT delivery of ASOs and siRNAs?
- What are regulators looking for in safe and scalable IT formulations, and how can we align preclinical testing with clinical expectations?
- What are the risks of bolus dosing on CSF composition, and how can formulation mitigate neurotoxicity across species?
