Sonu Kumar
Principal Scientist Bristol Myers Squibb
Sonu Kumar, Ph.D., is a Principal Scientist in Protein Engineering at Bristol Myers Squibb, where he leads efforts in antibody engineering and CNS biologics. His work focuses on developing next-generation multispecific antibodies and blood–brain barrier delivery platforms to enable transformative therapies for neurological disorders. He combines expertise in protein engineering, structural biophysics, and computational design to drive innovation in biologics discovery.
Seminars
Wednesday 2nd December 2026
Advancing CNS Development Candidates Through Translational Discovery & Humanized Models to Optimize Brain Exposure
1:30 pm
- Integrating translational discovery workflows to link target biology with PK/PD and enable progression from early discovery through to development candidate selection
- Applying humanized mouse models to generate human-relevant CNS exposure and distribution data, strengthening confidence in translational predictability
- Enhancing brain exposure through structure–property optimisation, transporter-aware design, and minimizing efflux liability during lead optimization
- Using in vivo exposure–response relationships and translational modelling to de-risk candidate selection and support robust IND-enabling strategies
