Ajay Verma
Founding Scientist Lotus Neuroscience
Seminars
Tuesday 1st December 2026
Focused Ultrasound vs Brain Shuttles – Comparing Clinical Scalability for BBB Penetration
9:00 am
Enabling the direct comparison between focused ultrasound-mediated BBB opening and systemic brain shuttle approaches, examining the clinical viability, scalability, and commercial reality of each strategy.
This workshop will gather experts to:
- Evaluate clinical evidence and patient safety data for focused ultrasound BBB disruption versus systemic TfR1 shuttles to determine which approach delivers superior therapeutic outcomes with acceptable risk profiles
- Compare capital equipment requirements, procedure complexity, and reimbursement pathways for FUS against manufacturing scalability and cost-of-goods for antibody shuttles to assess commercial viability
- Explore combination strategies where FUS-enhanced delivery works synergistically with brain shuttles to achieve therapeutic concentrations in deep brain structures unreachable by either approach alone
Thursday 3rd December 2026
Targeted Blood Brain Barrier Opening Using Focused Ultrasound to Enable Spatially Precise CNS Drug Delivery Without Molecular Re-Engineering
1:00 pm
- Demonstrating transient and region-specific BBB opening using microbubble-mediated focused ultrasound with reproducible safety across 300+ patients
- Enabling localized delivery of biologics, oligonucleotides and gene therapies with preserved molecular integrity and enhanced target engagement
- Quantifying biodistribution shifts and pharmacodynamic effects following ultrasound-mediated BBB modulation in oncology and neurodegeneration
- Positioning focused ultrasound within the broader CNS delivery toolkit alongside intrathecal dosing and receptor-mediated transport approaches
