Panel Discussion: Improving Brainshuttle Chemistry for Enhanced Brain Delivery & Distribution Through the Brain
2:00 pm - Wednesday 2nd December 2026
- What are the biggest chemistry-related barriers preventing today’s brain shuttles from achieving broad and uniform distribution throughout the brain?
- How should developers balance BBB crossing efficiency against intracellular release, tissue penetration, and target engagement when designing next-generation conjugates?
- Which molecular properties are most predictive of successful translation from preclinical brain exposure data to human efficacy?
- Will future breakthroughs come primarily from improved shuttle architectures, oligonucleotide chemistry, payload engineering, or combinations of all three?
