Novel AAV Capsids Enable Modular Tropism for Brain, Liver & Muscle with Minimized Hepatotoxicity
Time: 1:30 pm
day: Day One - Afternoon - Track A
Details:
- Engineering capsids with surface-displayed mini antibodies to facilitate receptor-mediated transcytosis across the blood-brain barrier
- Introducing targeted mutations in capsid loop regions to abrogate liver receptor binding, achieving a reduction in hepatic tropism
- Incorporating muscle-specific targeting peptides to create a modular vector platform with tuneable multi-organ tropism profiles
