Novel AAV Capsids Enable Modular Tropism for Brain, Liver & Muscle with Minimized Hepatotoxicity
- Engineering capsids with surface-displayed mini antibodies to facilitate receptor-mediated transcytosis across the blood-brain barrier
- Introducing targeted mutations in capsid loop regions to abrogate liver receptor binding, achieving a reduction in hepatic tropism
- Incorporating muscle-specific targeting peptides to create a modular vector platform with tuneable multi-organ tropism profiles