Leveraging AI-Powered Natural Nanoparticles: A Novel Dual-Mechanism Shuttle for Enhanced BBB Penetration & Parenchymal Delivery
Time: 2:00 pm
day: Day One - Afternoon - Track A
Details:
- Introducing the dtBBB-NNP platform, engineered using a proprietary AI-driven engine (NNP Design AI™) to ensure predictable and robust Blood-Brain Barrier penetrating capabilities for next-generation CNS therapeutics
- Elucidating the novel dual-mechanism of action that facilitates highly efficient transcytosis across the BBB, enabling targeted delivery of a wide range of therapeutic payloads including oligonucleotides (ASO, siRNA) and enzymes
- Presenting compelling preclinical in vivo data demonstrating significant payload accumulation in the brain parenchyma and specific uptake by key CNS cell types, and discussing the platform’s cGMP-readiness for clinical translation
