Keynote: Why is it so much Harder to Deliver Oligonucleotides to the Brain Compared to Other Organs?
9:00 am - Wednesday 2nd December 2026
- Exploring that the rate-limiting step for oligonucleotides targeted for CNS indications is release of oligonucleotides from lysosome and brain tissue
- Evaluating novel delivery technologies across LNPs, ultrasound, viral particles and routes of administration in delivering oligonucleotides to the brain without compromising on potency, distribution, affinity or efficacy
- Reviewing the next step to optimizing structural design to ensure delivery to the cytoplasm and nucleus
