Formulation Strategies for Long-Acting Injectable Prodrugs in Schizophrenia: Reducing Dosing Burden
Time: 9:30 am
day: Day One - Morning
Details:
- Designing prodrugs for extended CNS exposure: How modulation of physicochemical properties supports monthly or longer dosing for conditions like schizophrenia
- Overcoming high-load suspension issues, selecting excipients, and optimizing vehicles for improved injectability and stability
- Trends toward patient-centric administration (e.g., subcutaneous), potential for at-home use, and innovations in drug-device combinations
- Approaches to modulating physicochemical properties (e.g., solubility, lipophilicity) and overcoming challenges in formulating high-concentration suspensions for extended release
- Lessons learned from preclinical candidate selection, vehicle optimization, and preparing for clinic – highlighting the formulation’s path from bench to bedside
