Focused Ultrasound vs Brain Shuttles – Comparing Clinical Scalability for BBB Penetration
9:00 am - Tuesday 1st December 2026
Enabling the direct comparison between focused ultrasound-mediated BBB opening and systemic brain shuttle approaches, examining the clinical viability, scalability, and commercial reality of each strategy.
This workshop will gather experts to:
- Evaluate clinical evidence and patient safety data for focused ultrasound BBB disruption versus systemic TfR1 shuttles to determine which approach delivers superior therapeutic outcomes with acceptable risk profiles
- Compare capital equipment requirements, procedure complexity, and reimbursement pathways for FUS against manufacturing scalability and cost-of-goods for antibody shuttles to assess commercial viability
- Explore combination strategies where FUS-enhanced delivery works synergistically with brain shuttles to achieve therapeutic concentrations in deep brain structures unreachable by either approach alone
