Evaluating the Potential of Alternative Receptors Beyond TfR1 to Enhance CNS Access
Time: 11:30 am
day: Day Two - Morning - Track A
Details:
- What properties make a receptor suitable for CNS transcytosis?
- How do you evaluate receptor internalization and trafficking?
- Are we reaching the limits of TfR, or is there more to explore?
- What’s needed to validate a “novel” receptor target clinically?
- Couple single-domain antibodies to Fc regions or other antibodies to enhance pharmacokinetics and prolong half-life
