Dose Scaling from NHP to Human: PKPD Modelling & Safety Margin Determination
1:00 pm - Thursday 3rd December 2026
- Build physiologically-based pharmacokinetic models that account for CSF volume, turnover rates, and brain tissue penetration to improve dose predictions
- Translate doses from non-human primates to humans using exposure-based rather than simple body weight scaling to improve safety margins
- Integrate target engagement biomarkers and pharmacodynamic endpoints into models that predict efficacious human doses
