Advancing CNS Development Candidates Through Translational Discovery & Humanized Models to Optimize Brain Exposure
1:30 pm - Wednesday 2nd December 2026
- Integrating translational discovery workflows to link target biology with PK/PD and enable progression from early discovery through to development candidate selection
- Applying humanized mouse models to generate human-relevant CNS exposure and distribution data, strengthening confidence in translational predictability
- Enhancing brain exposure through structure–property optimisation, transporter-aware design, and minimizing efflux liability during lead optimization
- Using in vivo exposure–response relationships and translational modelling to de-risk candidate selection and support robust IND-enabling strategies
